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Poly (Lactic Acid)-chitosan-Collagen Composite Nanofibers as Substrates for Blood Outgrowth Endothelial Cells

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Biological Macromolecules

Source : International Journal of Biological Macromolecules, Volume 58, p.220-224 (2013)

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Keywords : animal cell, Animals, article, Blood Cells, blood outgrowth endothelial cell, cell adhesion, Cell Culture Techniques, cell function, cell proliferation, cell shape, cell structure, Cell Survival, cell type, cell viability, Cells, chitosan, collagen, controlled study, Culture Media, Cultured, Endothelial cells, endothelium cell, Fourier Transform Infrared, Lactic acid, molecular scaffold, nanocomposite, Nanofibers, Nitric Oxide Synthase Type III, nonhuman, polylactic acid, Polymers, rat, Rats, Regenerative medicine, Spectroscopy, Tissue Scaffolds

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move

Department : Nanosciences and Molecular Medicine

Year : 2013

Abstract : In this work, the attachment, viability and functionality of rat Blood Outgrowth Endothelial Cells (rBOEC) and genetically modified rBOEC (rBOEC/eNOS-GFP), which over express endothelial nitric oxide synthase (eNOS), were investigated on Poly(lactic acid) (PLA)-chitosan and PLA-chitosan-collagen nanofibrous scaffolds. Both the cell types displayed good attachment, remained viable and functional on both scaffolds. Moreover, incorporation of collagen in the scaffold helped in sustaining the rBOEC for upto one week, although collagen was not found necessary for rBOEC/eNOS-GFP. We conclude that PLA-chitosan based nanofibrous scaffolds can be a potential candidate for BOEC based wound healing applications. © 2013 Elsevier B.V.

Cite this Research Publication : B. Swarnalatha, Nair, S. L., ,, Paul-Prasanth, B., Krishnakumar N. Menon, Hebbel, R. P., Somani, A., Nair, S. V., Milbauer, L. C., and Jayakumar, R., “Poly (Lactic Acid)-chitosan-Collagen Composite Nanofibers as Substrates for Blood Outgrowth Endothelial Cells”, International Journal of Biological Macromolecules, vol. 58, pp. 220-224, 2013.

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