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Preparation of Budesonide-loaded Polycaprolactone Nanobeads by Electrospraying for Controlled Drug Release

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Journal of Biomaterials Science, Polymer Edition

Source : Journal of Biomaterials Science, Polymer Edition, Volume 22, Number 18, p.2431-2444 (2011)

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Keywords : aluminum foil, Applied voltages, aqueous solution, Aqueous suspensions, article, biocompatibility, Biodegradable polymers, budesonide, cancer cell culture, cell viability, concentration response, conductance, Controlled drug delivery, controlled drug release, controlled study, dispersion, Dissolution, drug absorption, drug cytotoxicity, drug distribution, Drug encapsulation efficiency, drug formulation, Drug products, drug solubility, drug structure, electric potential, electrospray, Electrospraying, encapsulation, Encapsulation efficiency, Experimental parameters, flow rate, human, human cell, humidity, in vitro study, In-vitro, Inflammatory disorders, Inherent

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2011

Abstract : Corticosteroids such as budesonide are the drugs of choice for the treatment of inflammatory disorders with an inherent limitation, viz., rapid elimination. To overcome this constraint and attain sustained release, budesonide was encapsulated in a biodegradable polymer, polycaprolactone (PCL), by DC electrospraying. By varying the experimental parameters involved in electrospraying such as applied voltage, flow rate, viscosity as well as conductivity of the polymer solution, the dimensionality of nanostructures was tuned from 1-D nanofibers to spherical nanoparticles. By adopting this rapid and viable method of DC electrospraying, we successfully prepared aqueous suspensions of nearly monodispersed, nano-sized drug encapsulated PCL. Drug encapsulation efficiency, in vitro drug release as well as biocompatibility studies of budesonide-loaded PCL nanobeads were carried out. The cytocompatible nanobeads prepared by electrospraying exhibited good encapsulation efficiency (approx. 75%), with controlled drug release enabled by the dissolution of the polymer. Our results demonstrate the potential of this novel technique of electrospraying in developing efficient drug encapsulated polymeric nanocarriers possessing sustained drug release profile. © 2011 Koninklijke Brill NV, Leiden.

Cite this Research Publication : B. T. Midhun, Shalumon, K. T., Manzoor, K., Dr. Jayakumar Rangasamy, Shantikumar V. Nair, and Deepthy, M., “Preparation of Budesonide-loaded Polycaprolactone Nanobeads by Electrospraying for Controlled Drug Release”, Journal of Biomaterials Science, Polymer Edition, vol. 22, pp. 2431-2444, 2011.

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