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Preparation of Poly(lactic acid)/chitosan Nanoparticles for Anti-HIV Drug Delivery Applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 80, Number 3, p.833 - 838 (2010)

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Keywords : chitosan, Controlled drug delivery, emulsion, Lamivudine drug, Nanoparticles, Poly(lactic acid)

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2010

Abstract : Poly(lactic acid) (PLA)/chitosan (CS) nanoparticles were prepared by emulsion method for anti-HIV drug delivery applications. The prepared PLA/CS nanoparticles were characterized using DLS, SEM, and FTIR. The hydrophilic antiretroviral drug Lamivudine was loaded into PLA/CS nanoparticles. The encapsulation efficiency and in-vitro drug release behaviour of drug loaded PLA/CS nanoparticles were studied using UV spectrophotometer. In addition, the cytotoxicity of the PLA/CS nanoparticles using MTT assay was also studied. The in-vitro drug release studies showed that drug release rate was lower in the acidic pH when compared to alkaline pH. This may due to repulsion between H+ ions and cationic groups present in the polymeric nanoparticles. Drug release rate was found to be higher in the 6% drug loaded formulation when compared to 3% drug loaded formulation. These results indicated that the PLA/CS nanoparticles are a promising carrier system for controlled delivery of anti-HIV drugs.

Cite this Research Publication : A. Dev, Binulal, N. S., Anitha, A., Nair, S. V., Furuike, T., Tamura, H., and Dr. Jayakumar Rangasamy, “Preparation of Poly(lactic acid)/chitosan Nanoparticles for Anti-HIV Drug Delivery Applications”, Carbohydrate Polymers, vol. 80, pp. 833 - 838, 2010.

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