Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : J Med Virol
Source : J Med Virol, Volume 93, Issue 8, p.5188-5192 (2021)
Url : https://pubmed.ncbi.nlm.nih.gov/33851736/
Keywords : HPV genotypes, HPV prevalence, HPV vaccine, India, Kerala, persistence.
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2021
Abstract : The prevalence of human papillomavirus (HPV) types varies geographically between various countries and different parts of the same country. The efficacy of the HPV vaccines is dependent on the prevalent HPV types. Here, we have studied the prevalence of high-risk HPV (hrHPV) and its genotypes in women in our population. Cervical samples of 2443 women were screened for the presence of hrHPV using the careHPV system. To determine the HPV genotypes, viral DNA was isolated from the hrHPV-positive samples, nested PCR was used to amplify the L1 hypervariable region, and was subjected to Sanger sequencing. The prevalence of hrHPV was found to be 2%. HPV16 (52%), HPV33 (40%), HPV18 (4%), HPV31 (2%), and HPV66 (2%) genotypes were found in this study. In Kerala, HPV16 and HPV33 genotypes were found to be significantly higher compared with the other HPV types detected. As the bivalent (Cervarix) and quadrivalent (Gardasil-4) vaccines offer limited cross-protection against HPV33, nonavalent (Gardasil 9) vaccine would be more effective in preventing cervical carcinoma in Kerala.
Cite this Research Publication : Alka Suresh, Parasmal Suresh, Dr. Raja Biswas, Anupama Rajanbabu, Sarala Sreedhar, and Dr. Lalitha Biswas, “Prevalence of high-risk HPV and its genotypes-Implications in the choice of prophylactic HPV vaccine.”, J Med Virol, vol. 93, no. 8, pp. 5188-5192, 2021.