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Prevalence of oral and systemic manifestations in pediatric HIV cohorts with and without drug therapy

Publication Type : Journal Article

Publisher : Current HIV Research, Bentham Science Publishers B.V.

Source : Current HIV Research, Bentham Science Publishers B.V., Volume 11, Number 6, p.498-505 (2013)

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Keywords : AIDS-Related Opportunistic Infections, Anti-HIV Agents, Antiretroviral Therapy, aphthous ulcer, article, breast feeding, Candidiasis, CD4 lymphocyte count, cheilitis, child, efavirenz, enzyme linked immunosorbent assay, erythema, erythematous candidiasis, female, hairy leukoplakia, Highly Active, highly active antiretroviral therapy, HIV Infections, human, Human immunodeficiency virus infection, Humans, hyperpigmentation, India, lamivudine plus stavudine, lamivudine plus zidovudine, lung tuberculosis, lymphadenopathy, Lymphatic Diseases, major clinical study, male, molluscum contagiosum, Mouth Diseases, mouth examination, multivitamin, nevirapine, otitis media, parotid enlargement, periodontitis, Pregnancy, Preschool, preschool child, prevalence, pseudomembraneous candidiasis, Respiratory Tract Infections, salbutamol, school child, seborrheic dermatitis, Skin Diseases, thrush, tooth infection, upper respiratory tract infection, Vincent stomatitis, virus infection, Western blotting

Campus : Kochi

School : School of Dentistry

Department : Oral Medicine and Radiology

Verified : Yes

Year : 2013

Abstract : The prevalence of orofacial and systemic manifestations and their association with drug therapy in pediatric HIV patients is scarce in the literature. The aim of the study was to determine the prevalence of oro-facial and systemic manifestations in HIV sero-positive children with and without highly active antiretroviral therapy (HAART). The study population consisted of 100 pediatric HIV patients (n=47 on HAART and n=53 not on HAART). The majority of the children (n=56) had at least one or more oro-facial manifestation associated with HIV. Oral candidiasis was the most common oral finding present in the HAART (14/33) and non-HAART groups (19/33). Recurrent aphthous ulcers was the only significant oral finding, present more in the HAART group. The percentage of children with upper respiratory tract infection was also more in the HAART group. The other lesions which were found to be significant were seborrheic dermatitis, pulmonary tuberculosis and otitis media. There was no significant difference in the participants' oral findings based on CD4 counts in the HAART and non- HAART groups. The prevalence of oral and systemic manifestations is a persistent feature associated with pediatric HIV, though of moderate intensity in those using HAART and may vary according to individual immune status. © 2013 Bentham Science Publishers.

Cite this Research Publication : R. Jose, Chandra, Sb, Puttabuddi, J. Hc, Vellappally, Sde, Khuraif, A. - A. AeAl, Halawany, H. Sfg, Abraham, N. Bf, Jacob, Vf, and Hashim, Mde, “Prevalence of oral and systemic manifestations in pediatric HIV cohorts with and without drug therapy”, Current HIV Research, vol. 11, pp. 498-505, 2013.

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