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Redox-responsive xanthene–coumarin–chlorambucil-based FRET-guided theranostics for “activatable” combination therapy with real-time monitoring†

Publication Type : Journal Article

Source : Chem. Commun

Url :

Campus : Amritapuri

School : School of Physical Sciences

Department : Chemistry

Year : 2017

Abstract : A FRET donor–acceptor xanthene–coumarin conjugate has been designed for redox-regulated synergic treatment of photodynamic therapy and chemotherapy with real-time monitoring. The “locked” FRET pair was selectively “unlocked” by biological reducing thiols via rupture of a sacrificial disulfide linker. A distinct change in fluorescence color and selective cancer cell toxicity were observed in vitro.

Cite this Research Publication : Moumita Gangopadhyay, Rakesh Mengji, Amrita Paul, Yarra Venkatesh, Venugopal Vangala, Dr. Avijit Jana, Dr. N D Pradeep Singh. Redox-responsive Xanthene-Coumarin-Chlorambucil- based FRET-guided Theranostics for “Activatable” Combination Therapy with Real-Time Monitoring. Chem. Commun. 2017, 53(65), 9109-9112. [DoI: 10.1039/c7cc03241b]

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