Publication Type : Journal Article
Source : Chem. Commun
Url : https://pubs.rsc.org/en/content/articlehtml/2017/cc/c7cc03241b
Campus : Amritapuri
School : School of Physical Sciences
Department : Chemistry
Year : 2017
Abstract : A FRET donor–acceptor xanthene–coumarin conjugate has been designed for redox-regulated synergic treatment of photodynamic therapy and chemotherapy with real-time monitoring. The “locked” FRET pair was selectively “unlocked” by biological reducing thiols via rupture of a sacrificial disulfide linker. A distinct change in fluorescence color and selective cancer cell toxicity were observed in vitro.
Cite this Research Publication : Moumita Gangopadhyay, Rakesh Mengji, Amrita Paul, Yarra Venkatesh, Venugopal Vangala, Dr. Avijit Jana, Dr. N D Pradeep Singh. Redox-responsive Xanthene-Coumarin-Chlorambucil- based FRET-guided Theranostics for “Activatable” Combination Therapy with Real-Time Monitoring. Chem. Commun. 2017, 53(65), 9109-9112. [DoI: 10.1039/c7cc03241b]