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Stereoselective alkylation of imines and its application towards the synthesis of β-lactams

Publication Type : Journal Article

Publisher : Wiley

Source : Asian Journal of Organic Chemistry, 2016

Campus : Amritapuri

School : School of Biotechnology

Verified : No

Year : 2016

Abstract : (S)‐4‐Isopropyl‐1‐[(R)‐1‐phenylethyl]imidazolidin‐2‐one was evaluated as a chiral auxiliary for asymmetric acetate and propionate Mannich‐type reactions, by generation of the titanium enolates, affording excellent yields and stereoselectivities. The application of the auxiliary was exemplified in the stereoselective synthesis of the β‐lactam antihyperlipidemic drug ezetimibe.

Cite this Research Publication : Sandeep Goyal, Anamika Thakur, Ratnesh Sharma, Mukesh Gangar, Bhautikkumar Patel and Vipin A. Nair, "Stereoselective Alkylation of Imines and its Application towards the Synthesis of β‐Lactams", Asian Journal of Organic Chemistry 2016, 5, 1359-1367

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