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Surface engineering at the nanoscale: A way forward to improve coronary stent efficacy

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : APL Bioengineering.

Source : APL Bioengineering, Volume 5, Issue 2, p.021508 (2021)

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Campus : Amritapuri

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move

Department : Nanosciences and Molecular Medicine

Year : 2021

Abstract : Coronary in-stent restenosis and late stent thrombosis are the two major inadequacies of vascular stents that limit its long-term efficacy. Although restenosis has been successfully inhibited through the use of the current clinical drug-eluting stent which releases antiproliferative drugs, problems of late-stent thrombosis remain a concern due to polymer hypersensitivity and delayed re-endothelialization. Thus, the field of coronary stenting demands devices having enhanced compatibility and effectiveness to endothelial cells. Nanotechnology allows for efficient modulation of surface roughness, chemistry, feature size, and drug/biologics loading, to attain the desired biological response. Hence, surface topographical modification at the nanoscale is a plausible strategy to improve stent performance by utilizing novel design schemes that incorporate nanofeatures via the use of nanostructures, particles, or fibers, with or without the use of drugs/biologics. The main intent of this review is to deliberate on the impact of nanotechnology approaches for stent design and development and the recent advancements in this field on vascular stent performance.

Cite this Research Publication : Aleena Mary Cherian, Shantikumar V Nair, Vijayakumar Maniyal, and Dr. Deepthy Menon, “Surface engineering at the nanoscale: A way forward to improve coronary stent efficacy”, APL Bioengineering, vol. 5, no. 2, p. 021508, 2021.

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