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Synthesis and Anti-Staphylococcal Activity of TiO2 Nanoparticles and Nanowires in Ex Vivo Porcine Skin Model

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Journal of Biomedical Nanotechnology

Source : Journal of Biomedical Nanotechnology, Volume 10, Number 5", publication date ="2014-05-01T00:00:00, p.864-870 (2014)

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Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2014

Abstract : Staphylococcus aureus is one of the major causes of skin and soft tissue infections. In this study we compared the antimicrobial activity of two different TiO2 nanoformulations against Staphylococcus aureus. We synthesized TiO2 nanoparticles of 80 nm diameter and TiO2 nanowires of 100 nm diameter. Both nanoformulations possess anti-microbial activity; were non-hemolytic and cytocompatible. However, the anti-staphylococcal activity of TiO2 nanowires was better than the nanoparticles. In broth culture, growth of S. aureus was only partially inhibited by 2% and 4 wt% TiO2 nanoparticles and completely inhibited by TiO2 nanowires till 24 h. TiO2 nanowires treated S. aureus cells exhibits diminished membrane potential than nanoparticle treated cells. The anti-microbial properties of both TiO2 nanoformulations were validated using ex vivo porcine skin model which supplements the in vitro assays. Anti-bacterial activity of the TiO2 nanowires were also validated against multi drug resistant pathogenic strains of S. aureus, showing the clinical potency of the TiO2 nanowires compared to its nanoparticles.

Cite this Research Publication : N. Nataraj, Anjusree, G. S., Madhavan, A. Anish, Priyanka, P., Sankar, D., Nisha, N., Dr. Lakshmi Sumitra, Dr. Jayakumar Rangasamy, Balakrishnan, A., and Dr. Raja Biswas, “Synthesis and Anti-Staphylococcal Activity of TiO2 Nanoparticles and Nanowires in Ex Vivo Porcine Skin Model”, Journal of Biomedical Nanotechnology, vol. 10, pp. 864-870, 2014.

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