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Synthesis and preliminary evaluation of a focused chalcone library for anti-inflammatory activity

Publication Type : Journal Article

Publisher : Ind J Pharm Educ Res

Source : Ind J Pharm Educ Res, Volume 47, Number 4, p.31–38 (2013)

Url : http://www.ijper.org/sites/default/files/ijper_47_4_5.pdf

Campus : Kochi

School : School of Pharmacy

Department : Pharmaceutical Chemistry & Analysis

Verified : Yes

Year : 2013

Abstract : A series of monosubstituted chalcones with potential anti-inflammatory activity have been rationally designed leading to a focused library of ligands 4a-j with ring-A substitution. Subsequent to drug-likeness and druggability assessments, the library members were synthesized in optimal yields and their structures were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. Screening for anti-inflammatory activity revealed that most of the compounds were quite effective in containing inflammation with compound 4b being the most promising derivative

Cite this Research Publication : R. Balasubramanian, Iqbal, H., Vijayagopal, R., and Chandrika, B., “Synthesis and preliminary evaluation of a focused chalcone library for anti-inflammatory activity”, Ind J Pharm Educ Res, vol. 47, pp. 31–38, 2013.

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