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Synthesis, Characterization and Cytocompatibility Studies of α-chitin Hydrogel/nano Hydroxyapatite Composite Scaffolds

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Biological Macromolecules

Source : International Journal of Biological Macromolecules, Volume 49, Number 1, p.20-31 (2011)

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Keywords : adsorption, alpha chitin, animal cell, Animals, article, biocompatibility, biomineralization, cell adhesion, cell proliferation, cell spreading, Cell Survival, cell viability, Cercopithecus aethiops, chemical analysis, chitin, controlled study, Cytocompatibility, degradation, Durapatite, Electron, Fourier Transform Infrared, freeze drying, human, human cell, Humans, hydrogel, infrared spectroscopy, light scattering, Mice, microscopy, mouse, nanocomposite, nanofabrication, nanohydroxyapatite, Nanostructures, NIH 3T3 Cells, nonhuman, porosity, Scanning, scanning electron microscopy, Spectroscopy, Thermogravimetry, tissue engineering, Tissue Scaffolds, unclassified drug, Vero cells, Wound healing, X ray diffraction, X-Ray Diffraction

Campus : Kochi

School : Center for Nanosciences, School of Dentistry

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Periodontics, Nanosciences and Molecular Medicine

Year : 2011

Abstract : α-chitin hydrogel/nano hydroxyapatite (nHAp) composite scaffold have been synthesized by freeze-drying approach with nHAp and α-chitin hydrogel. The prepared nHAp and nanocomposite scaffolds were characterized using DLS, SEM, FT-IR, XRD and TGA studies. The porosity, swelling, degradation, protein adsorption and biomineralization (calcification) of the prepared nanocomposite scaffolds were evaluated. Cell viability, attachment and proliferation were investigated using MG 63, Vero, NIH 3T3 and nHDF cells to confirm that the nanocomposite scaffolds were cytocompatible and cells were found to attach and spread on the scaffolds. All the results suggested that these scaffolds can be used for bone and wound tissue engineering.

Cite this Research Publication : P. T. S. Kumar, Sowmya Srinivasan, Lakshmanan, V. - K., Tamura, H., Nair, S. V., and Dr. Jayakumar Rangasamy, “Synthesis, Characterization and Cytocompatibility Studies of α-chitin Hydrogel/nano Hydroxyapatite Composite Scaffolds”, International Journal of Biological Macromolecules, vol. 49, pp. 20-31, 2011.

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