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Synthesis of Electrospun Silica Nanofibers for Protein/DNA Binding

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Materials Letters.

Source : Materials Letters, Volume 184, p.5 - 8 (2016)

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Keywords : Bioceramics, DNA/Protein binding, Electrospinning, Functional, Polymers, Silica nanofibers

Campus : Amritapuri, Kochi

School : Center for Nanosciences

Center : Amrita Centre for Advanced Research in Ayurveda, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2016

Abstract : Silica is widely used as the nanomaterial carrier for DNA or protein delivery because of ease and multitude of methods for its synthesis and relatively simple ways with which its surface chemistry can be modified. In the present study, electrospun nano scale silica fibrous mats with diameters in the range of 250–320nm were synthesized using TEOS (Tetra ethyl ortho silicate) as a silica precursor along with Poly (vinyl pyrolidine) (PVP). These fibrous mats were used for effective binding/elution of plasmid DNA and BSA (Bovine Serum Albumin) under optimal conditions, which were demonstrated utilizing this combination of electrospun silica precursor and PVP. These silica fiberous mats are easier to control than silica nanoparticles and require less hazardous preparation than nanosheets developed via etching. The developed nanosilica mats could be a cost effective tool for DNA and protein delivery for different biotechnological and medical applications

Cite this Research Publication : R. Anney Matthew, Minsha Mallika Gopi, Menon, P., Dr. Jayakumar Rangasamy, and Dr. Lakshmi Sumitra, “Synthesis of Electrospun Silica Nanofibers for Protein/DNA Binding”, Materials Letters, vol. 184, pp. 5 - 8, 2016

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