Publication Type : Journal Article
Publisher : Journal of Chemical Sciences
Source : Journal of Chemical Sciences, 133(1), 2021, DOI:10.1007/s12039-020-01872-4
Campus : Kochi
School : School of Pharmacy
Year : 2021
Abstract : A novel series of analogues based on 5-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-4-phenyl-2H-1,2,4-triazole-3(4H)-thione core have been synthesized and their potential as antibacterial, antifungal and antitubercular agents was examined. The structure-activity relationship (SAR) studies of these derivatives 5 (a–k) clearly indicate the vital role of lipophilicity as a major factor in enhancing the biological activity of these compounds. Among the compounds screened, 5a, 5c, 5d, 5j and 5k displayed significant activity against Mycobacterium tuberculosis H37Rv strain.
Cite this Research Publication : Rishikesan, R., Karuvalam, R.P., Muthipeedika, N.J., Narasimhamurthy, K.H., Muralidharan, A., "Synthesis of some novel piperidine fused 5-thioxo-1H-1,2,4-triazoles as potential antimicrobial and antitubercular agents", Journal of Chemical Sciences, 133(1), 2021, DOI:10.1007/s12039-020-01872-4