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Synthetic Approaches to Various Class of Topoisomerase II Inhibitors

Publication Type : Journal Article

Publisher : Mini-Reviews in Organic Chemistry

Source : Mini-Reviews in Organic Chemistry, Volume 14, p.357-374 (2017)

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Keywords : antineoplastic agent., etoposide, mitoxantrone, pharmacophoresm, podophyllotoxin, Topoisomerase II

Campus : Kochi

School : School of Pharmacy

Center : Amrita Institute of Medical Science

Department : Pharmaceutical Chemistry & Analysis

Year : 2017

Abstract : Considering the diverse applications and importance of DNA topoisomerases II (TOP II) inhibitorsin biological systems, it is vital to understand the fundamental organic chemistry of these inhibitoryagents through various synthetic strategies and it is crucial for further developments of thesame. Many of the reported TOP II inhibitors are associated with extreme structural complexities andrequire multi-step synthetic routes providing difficulties towards their preparation and modifications.The present work describes the synthetic protocols for a diverse array of candidates relating to bothTOP II poisons and catalytic inhibitors which may be useful for further synthetic developments.

Cite this Research Publication : S. Dev, Gabhe, N., Dhaneshwar, S. R., Joy, M., and Bijo Mathew, “Synthetic Approaches to Various Class of Topoisomerase II Inhibitors”, Mini-Reviews in Organic Chemistry, vol. 14, pp. 357-374, 2017.

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