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Transient cytotoxicity of 131I beta radiation in hyperthyroid patients treated with radioactive iodine

Publication Type : Journal Article

Publisher : Indian Journal of Medical Research

Source : Indian Journal of Medical Research, Volume 133, Number 4, p.401-406 (2011)

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Keywords : Administration, adult, article, autonomous toxic nodule, Beta Particles, beta radiation, blood sampling, carbimazole, cell damage, chromosome aberration, Chromosome Aberrations, Chromosome-Defective, clinical article, controlled study, cytogenetics, cytotoxicity, drug safety, Electron, female, Graves disease, human, human cell, Humans, hyperthyroidism, iodine 131, Iodine Radioisotopes, low drug dose, male, metabolism, methodology, Micronuclei, micronucleus, micronucleus test, Micronucleus Tests, middle aged, Oral, oral drug administration, pathology, peripheral lymphocyte, Radiation Dosage, radiation dose, radiation exposure, radioactive iodine, sodium iodide i 131, thyroid gland, toxic goiter

Campus : Kochi

School : School of Medicine

Department : Nuclear Medicine

Year : 2011

Abstract : Background amp; objectives: Radioiodine (131I) or radioactive iodine in low doses is used worldwide as the first line of management in the treatment of hyperthyroidism. Information is available on the extent and severity of cell damage after a high dose radioiodine (131I) therapy for thyroid cancer, but information is scanty on its cellular effects, its extent and severity of cell damage after a low dose 131I therapy. The present investigation was aimed to study the cytotoxic effects of a low dose 131I therapy in varying doses as is normally being used in routine clinical practice in the treatment of various forms of hyperthyroidism. Methods: Peripheral blood lymphocytes were analyzed in 32 hyperthyroid patients. All of them received 131I in the form of sodium iodide solution orally. Blood lymphocytes were studied for the presence of chromosomal aberrations (CA) and micro nucleus (MN) using micronucleus assay. Blood samples of these patients were drawn prior to the treatment, on 7th and 30th days after the treatment. Results: The results indicated a positive relationship between 131I dose, CA and MN frequency. A statistically significant increase in CA and MN frequency in day 7 post- therapy and a decrease in mean levels of CA and MN on day 30 post-therapy were observed when compared to pre-therapy. Interpretation amp; conclusions: This study showed that the cytogenetic damage induced by 131I in low doses i.e., less than 555MBq was minimal and reversible. Patients can be motivated to undertake this safe and easy procedure as a first line of therapy in the treatment of hyperthyroidism.

Cite this Research Publication : PaShanmuga Sundaram, Padma, Sa, Sudha, Sb, and Sasikala, Kc, “Transient cytotoxicity of 131I beta radiation in hyperthyroid patients treated with radioactive iodine”, Indian Journal of Medical Research, vol. 133, pp. 401-406, 2011.

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