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Vasoconstrictor and coagulation activator entrapped chitosan based composite hydrogel for rapid bleeding control

Publication Type : Journal Article

Thematic Areas : Medical Sciences, Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Elsevier BV, Volume 258 (2021)

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Keywords : calcium, Coagulation activator, hemostatic agent, Injectable chitosan hydrogel, Potash alum, Vasoconstrictor

Campus : Kochi

School : Center for Nanosciences, School of Medicine

Center : Nanosciences

Department : C. V. T. S, Nanosciences and Molecular Medicine

Year : 2021

Abstract : Chitosan (Cs) as a hemostatic agent has been in use to control hemorrage. Composite hydrogel formed by entrapment of vasoconstrictor-potassium aluminium sulfate (0.25 %PA) and coagulation activator-calcium chloride (0.25 %Ca) into Cs (2 %) hydrogel would enhance the hemostatic property of Cs. In this work, the prepared composite hydrogel was injectable, shear thinning, cyto and hemocompatible. The 2 %Cs-0.25 %PA-0.25 %Ca composite hydrogel caused rapid blood clotting by accelerating RBC/platelet aggregation and activation of the coagulation cascade. Further, in vivo studies on rat liver and femoral artery hemorrage model showed the efficiency of 2 %Cs-0.25 %PA-0.25 %Ca composite hydrogel to achieve hemostasis in a shorter time (20 ± 10 s, 105 ± 31 s) than commercial hemostatic agents-Fibrin sealant (77 ± 26 s, 204 ± 58 s) and Floseal (76 ± 15 s, 218 ± 46 s). In in vivo toxicological study, composite hydrogel showed material retention even after 8 weeks post-surgery, therefore excess hydrogel should be irrigated from site of application. This prepared composite hydrogel based hemostatic agent has potential application in low pressure bleeding sites.

Cite this Research Publication : N. M. Sundaram, Ullas Mony, Dr. Praveen Varma, and Dr. Jayakumar Rangasamy, “Vasoconstrictor and coagulation activator entrapped chitosan based composite hydrogel for rapid bleeding control”, Carbohydrate Polymers, vol. 258, 2021.

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