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Vulvar carcinoma in Fanconi Anaemia: A case report with review of literature

Publication Type : Journal Article

Publisher : Gynecologic Oncology Reports

Source : Gynecologic Oncology Reports, 2021, 37,100841, DOI: https://doi.org/10.1016/j.gore.2021.100841

Url : https://www.sciencedirect.com/science/article/pii/S2352578921001454

Keywords : Fanconi anaemia, Vulvar cancer, Squamous cell carcinoma, Genome instability, DNA repair, Vaginal cancer

Campus : Kochi

School : School of Medicine, School of Pharmacy

Department : Medical Oncology, Gynecological Oncology, Pharmacy Practice

Year : 2021

Abstract : Fanconi anaemia is a rare autosomal recessive disorder associated with bone marrow failure and congenital malformations. The impaired DNA repair pathways in Fanconi anaemia predispose patients to a high risk of cancers of squamous cell origin, particularly in the head and neck region. Cancers of the vagina and vulva are rare in Fanconi anaemia. Here, we report a case of a 44-year-old female with Fanconi anaemia who developed an ulcerated lesion on the clitoris that extended into the labia majora. A biopsy of the lesion showed well-differentiated squamous cell carcinoma. The patient was treated with wide local excision of the vulval lesion. The patient developed neutropenia post-procedure but recovered in one week time. We have followed up the patient regularly since the procedure. No further issues have been detected to date.

Cite this Research Publication : Visweswaran, V., Jayamohanan, H., Rajanbabu, A., Pavithran, K., Vulvar carcinoma in Fanconi Anaemia: A case report with review of literature, Gynecologic Oncology Reports, 2021, 37,100841, DOI: https://doi.org/10.1016/j.gore.2021.100841

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