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Wet Chemical Synthesis of Chitosan Hydrogel–hydroxyapatite Composite Membranes for Tissue Engineering Applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Biological Macromolecules

Source : International Journal of Biological Macromolecules, Volume 45, Number 1, p.12 - 15 (2009)

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Keywords : Biomaterials, Chitosan hydrogel membranes, Composite membranes, Hydroxyapatite, tissue engineering

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2009

Abstract : Chitosan, a deacetylated derivative of chitin is a commonly studied biomaterial for tissue-engineering applications due to its biocompatibility, biodegradability, low toxicity, antibacterial activity, wound healing ability and haemostatic properties. However, chitosan has poor mechanical strength due to which its applications in orthopedics are limited. Hydroxyapatite (HAp) is a natural inorganic component of bone and teeth and has mechanical strength and osteoconductive property. In this work, HAp was deposited on the surface of chitosan hydrogel membranes by a wet chemical synthesis method by alternatively soaking the membranes in CaCl2 (pH 7.4) and Na2HPO4 solutions for different time intervals. These chitosan hydrogel–HAp membranes were characterized using SEM, AFM, EDS, FT-IR and XRD analyses. MTT assay was done to evaluate the biocompatibility of these membranes using MG-63 osteosarcoma cells. The biocompatibility studies suggest that chitosan hydrogel–HAp composite membranes can be useful for tissue-engineering applications.

Cite this Research Publication : K. Madhumathi, Shalumon, K. T., Rani, V. V. Divya, Tamura, H., Furuike, T., Selvamurugan, N., Nair, S. V., and Dr. Jayakumar Rangasamy, “Wet Chemical Synthesis of Chitosan Hydrogel–hydroxyapatite Composite Membranes for Tissue Engineering Applications”, International Journal of Biological Macromolecules, vol. 45, pp. 12 - 15, 2009.

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