Syllabus
History & Basic concepts of development
- Overview of how the modern era of developmental biology emerged through multidisciplinary approaches
- stages of development- zygote, blastula, gastrula ,neurula
- cell fate & commitment – potency- concept of embryonic stem cells, differential gene expression, terminal differentiation ,lineages of three germ layers, fate map
- Mechanisms of differentiation- cytoplasmic determinants, embryonic induction, concept of morphogen, mosaic and regulative development
- Pattern formation– axis specification, positional identification (regional specification)
- Morphogenetic movements
- Model organisms in Developmental biology
2. Early Development in invertebrate /vertebrate models
- Drosophila, C.elegans, Xenopus, Mouse/ human
- Cleavage, gastrulation, Axis specification (Dorsoventral, anterior posterior), & body plan patterning, left right asymmetry in vertebrates
3. Late Development in invertebrate /vertebrate models
Organogenesis- development of central nervous system in vertebrates, vulval formation in C.elegans
4. Germ cell specification& migration
5. Overview of plant development
6. Medical implications of developmental biology - genetic errors/ teratogenesis/ stem cell therapy etc
