Unit I

(10 Hours)

Impurities in pharmaceutical substances: History of Pharmacopoeia, Sources and types of impurities, principle involved in the limit test for Chloride, Sulphate, Iron, Arsenic, Lead and Heavy metals, modified limit test for Chloride and Sulphate

General methods of preparation, assay for the compounds superscripted with asterisk (*), proper- ties and medicinal uses of inorganic compounds belonging to the following classes

Unit II

(10 Hours)

Acids, Bases and Buffers: Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic solutions, measurements of tonicity, calculations and methods of adjusting

Major extra and intracellular electrolytes: Functions of major physiological ions, Electrolytes used in the replacement therapy: Sodium chloride*, Potassium chloride, Calcium gluconate* and Oral Rehydration Salt (ORS), Physiological acid base

Dental products: Dentifrices, role of fluoride in the treatment of dental caries, Desensitizing agents, Calcium carbonate, Sodium fluoride, and Zinc eugenol

Unit III

(10 Hours)

Gastrointestinal agents

Acidifiers: Ammonium chloride* and Dil. HCl

Antacid: Ideal properties of antacids, combinations of antacids, Sodium Bicarbonate*, Aluminum hydroxide gel, Magnesium hydroxide mixture

Cathartics: Magnesium sulphate, Sodium orthophosphate, Kaolin and Bentonite

Antimicrobials: Mechanism, classification, Potassium permanganate, Boric acid, Hydrogen perox- ide*, Chlorinated lime*, Iodine and its preparations

Unit IV

(08 Hours)

Miscellaneous compounds

Expectorants: Potassium iodide, Ammonium chloride*. Emetics: Copper sulphate*, Sodium potassium tartarate Haematinics: Ferrous sulphate*, Ferrous gluconate

Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrite333

Astringents: Zinc Sulphate, Potash Alum

Unit V

(07 Hours)

Radiopharmaceuticals: Radio activity, Measurement of radioactivity, Properties of α, β, γ radiations, Half life, radio isotopes and study of radio isotopes – Sodium iodide I131, Storage conditions, precau- tions & pharmaceutical application of radioactive

‘Pharmaceutical Inorganic Chemistry (Theory)’ is a course offered in the first year of B. Pharm. program at School of Pharmacy, Health Sciences campus, Amrita Vishwa Vidyapeetham.

Scope:

This subject deals with the monographs of inorganic drugs and pharmaceuticals.

Objectives:

Upon completion of course student shall be able to

• know the sources of impurities and methods to determine the impurities in inorganic drugs and pharmaceuticals
• understand the medicinal and pharmaceutical importance of inorganic compounds

45 Hours