Course

Unit 1:
Introduction to Precision and Translational Medicine; Definition and principles of precision medicine, Overview of translational research continuum, Role of precision medicine in improving patient outcomes.
Unit 2:
Molecular Diagnostics and Genetic Testing; Techniques for DNA and RNA analysis, Next-generation sequencing technologies, Clinical applications of genetic testing in precision medicine
Unit 3:
Personalized Therapies and Targeted Treatment Approaches, Pharmacogenomics and individualized drug responses. Targeted therapies for cancer and other diseases; Immunotherapy and precision oncology
Unit 4:
Biomarker Discovery and Validation; Biomarker identification strategies, Validation methods for biomarker candidates, Clinical utility and implementation of biomarkers in precision medicine.
Unit 5:
Data Integration and Computational Approaches; Big data analytics in precision medicine, Machine learning and predictive modeling, Data integration platforms and resources.
Unit 6:
Implementation Strategies for Precision Medicine; Challenges in integrating precision medicine into healthcare systems, Ethical, legal, and social implications (ELSI) of precision medicine, Regulatory considerations and policy frameworks.
Unit 7:
Case Studies in Precision Medicine; Precision medicine initiatives and consortia, Success stories and lessons learned from precision medicine projects, Patient-centric approaches and patient engagement in precision medicine research.
Unit 8:
Future Directions and Emerging Technologies; Advancements in omics technologies, Integration of artificial intelligence and digital health in precision medicine, Global perspectives on precision medicine initiatives.

Preamble
Precision and Translational Medicine is a graduate-level course designed to provide students with an in-depth understanding of the principles, methodologies, and applications of precision medicine in translational research and clinical practice. The course will cover topics such as molecular diagnostics, personalized therapies, biomarker discovery, and implementation strategies. Through lectures, case studies, and hands-on activities, students will explore the interdisciplinary nature of precision medicine and its potential to revolutionize healthcare.

Course outcome

CO1: To understand the principles and concepts of precision medicine and translational research.
CO2: To explore molecular diagnostics techniques and their applications in precision medicine.
CO3: To learn about personalized therapies and targeted treatment approaches.
CO4: To examine strategies for biomarker discovery and validation in precision medicine.
CO5: To discuss the challenges and opportunities in implementing precision medicine in clinical practice.
CO6: To analyze case studies and real-world examples of precision medicine applications.
CO7: To develop critical thinking and problem-solving skills in the context of precision and translational medicine.

Program outcome (PO)

PO1: Utilize scientific principles and methodologies to design innovative solutions for data analysis, experimentation, and product development for challenges in translational research.
PO2: Recognize the importance of environmental sustainability in translational research and strive to minimize adverse environmental impacts.
PO3: Engage in ethical conduct, leadership, active listening, constructive feedback, and interpersonal communication to facilitate productive collaborations and knowledge exchange.
PO4: Acquire fundamental and advanced knowledge and skills in project management, financial planning, and entrepreneurship relevant to translational research ventures and initiatives.
3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – = No Affinity

Program Specific Outcome (PSO)

PSO1: Addresses the complexity of interdisciplinary sciences in biological and medical contexts.
PSO2: Deals with regulatory affairs in medicine, covering topics such as ethical considerations and regulatory frameworks.
PSO3: Covers compounds as drugs and their efficacy, involving pharmacology and drug development.
PSO4: Explores the intersection of bioinformatics and artificial intelligence in biology and medicine.
PSO5: Deals with technology in personalizing medicine, involving precision medicine approaches.
PSO6: Focuses on communicating and disseminating science and medicine to the public, involving science communication and public outreach efforts.

Martin Wehling, Principles of Translational Science in Medicine: From Bench to Bedside, Academic Press.