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A case report on phenytoin induced agranulocytosis and rash

Publisher : Journal of Pharmaceutical Sciences and Research

Campus : Kochi

School : School of Pharmacy

Department : Pharmacy Practice

Year : 2017

Abstract : pAgranulocytosis is a rare condition which is defined as reduction or an absolute lack of circulating granulocytes, typically neutrophil count less than 0.5 × 109/L. Phenytoin is a therapeutically effective anticonvulsant agent but it may causes adverse drug reactions as well. In rare cases, it may cause idiosyncratic reactions in the form of agranulocytosis. Over the years, skin rash also been identified as a hypersensitivity reaction to phenytoin. We present a case of a 59 year old male who suffered from an injury to the head and dorsum of right foot in a road traffic accident one month ago. He was admitted to a local hospital and was started on Phenytoin 100 mg for seizure prophylaxis as CT scan showed signs of subarachnoid hemorrhage (SAH). After taking the medication for two weeks, it was observed that his White blood cells (WBC) levels had serially decreased to 550/mm3 along with rash on trunk and generalized itching. © 2017, Pharmainfo Publications. All rights reserved./p

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