Publications

Abstract : The nanorods of vanadium oxide (V2O5) is synthesized by environmentally benign synthetic approach using a phytomolecule, 4-(3-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxymethyl)butyl)-3,6-dimethoxybenzene-1,2-diol, isolated from Phyllanthus amarus. The rod shaped V2O5 nanostructures with the widths about 10–60 nm and the lengths reaching up to 1.5 μm was evident from scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. The orthorhombic structure of V2O5 is apparent from X-ray diffraction (XRD) results. Furthermore, the crystalline nature of V2O5 nanorods was supported by the results of high-resolution TEM (HRTEM) and selected area electron diffraction (SAED) analysis, which showed that the interplanar distance between two lattice fringes is 0.33 nm corresponding to (001) reflection plane. The X-ray photoelectron spectroscopic (XPS) studies revealed that the peak at 533.6 eV indicates the presence of metal oxide and also confirms that the oxidation state of vanadium in as-prepared V2O5 is V5+. The scission of supercoiled plasmid DNA was observed from 2D gel-image, which clearly indicated that the propensity of plasmid cleavage increases with increase in concentration of V2O5 nanorods. Interestingly, high degree of cell viability with relatively less cytotoxicity was observed for V2O5 nanorods than phytomolecule in comparison with standard drug, Methotrexate against breast cancer cell line MDA MB 231 and MCF 12 A human cell line, respectively.