Publication Type : Journal Article
Publisher : Indian Journal of Pharmacology
Source : Indian Journal of Pharmacology, Volume 34(5) (2002)
Url : https://www.ijp-online.com/article.asp?issn=0253-7613;year=2002;volume=34;issue=5;spage=361;epage=362;aulast=George;type=0
Campus : Kochi
School : School of Pharmacy
Department : Pharmacy Practice
Year : 2002
Abstract : The effects of Bonny light crude oil on the smooth and skeletal muscles contraction and pain were investigated. Methods: Analgesic effect of Bonny light crude oil was tested in mice using acetic acid (0.75%)- induced writhing model. Its effects on histamine-, and Ach-induced smooth muscle contraction were studied in guinea pig ileum. The effects of crude oil on Ach-induced contraction of rat duodenum and frog rectus abdominis muscle were also studied. Results: The crude oil caused complete inhibition of histamine - induced smooth muscle contraction, while producing only a partial inhibition of the acetylcholine - induced contraction. It had no effects on the acetylcholine-induced skeletal muscle contraction, but showed good analgesic effect comparable to aspirin. Conclusion: The Bonny light crude oil possesses inhibitory action on smooth muscle contraction induced by histamine, and analgesic property.
Cite this Research Publication : K. K. V. George, Nagarajan, M., and Dr. M.P.Narmadha, “A study on drug prescribing pattern in Madurai city”, Indian Journal of Pharmacology, vol. 34(5), 2002.