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Publication Type : Presentation
Publisher : Research Day, Amrita School of Pharmacy
Source : Research Day, Amrita School of Pharmacy (Poster). Kochi, Kerala, India., 2017.
Campus : Kochi
School : School of Pharmacy
Center : Amrita Institute of Medical Science
Department : Pharmaceutics
Verified : Yes
Year : 2017
Abstract : Wound healing is a dynamic, interactive, and complex process, including multiple stages. Although various nanomaterials are applied to accelerate the wound healing process through exhibiting antibacterial activity or promoting cell proliferation, only a single stage is promoted during the process, lowering healing efficacy. It is necessary to develop programmable nanosystems for promoting multiple wound healing stages in sequence. Herein, arginine-loaded and detachable ceria-graphene nanocomposites (ACG NCs) were designed to achieve this purpose. Ceria NPs and graphene were linked by base-cleavable N-hydroxysuccinimide ester. At inflammation stage, ACG NCs could effectively generate reactive oxygen species (ROS) and kill bacteria under white light irradiation due to their efficient electron–hole separation between ceria NPs and graphene. At proliferation stage, ceria NPs could be detached from ACG NCs and taken up by cells to scarify intracellular ROS and promote cell proliferation, while the separated graphene could act as a scaffold to promote fibroblast migration to wound site. A series of in vitro and in vivo assessments demonstrated that ACG NCs could effectively accelerate wound healing process.
Cite this Research Publication : R. Rashmi and Dr. Kaladhar Kamalasanan, “Accelerated wound healing using nanosystems”, Research Day, Amrita School of Pharmacy (Poster). Kochi, Kerala, India., 2017.