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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Bioactive Materials
Source : Bioactive Materials
Keywords : Alginate nanobeads, Fibrin hydrogel, Soft tissue engineering
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2018
Abstract : Hydrogels are a class of materials that has the property of injectability and in situ gel formation. This property of hydrogels is manipulated in this study to develop a biomimetic bioresorbable injectable system of alginate nanobeads interspersed in fibrin network. Alginate nanobeads developed by calcium cross-linking yielded a size of 200–500 nm. The alginate nanobeads fibrin hydrogel was formed using dual syringe apparatus. Characterization of the in situ injectable hydrogel was done by SEM, FTIR and Rheometer. The developed hydrogel showed mechanical strength of 19 kPa which provides the suitable compliance for soft tissue engineering. Cytocompatibility studies using human umbilical cord blood derived mesenchymal stem cells showed good attachment, proliferation and infiltration within the hydrogel similar to fibrin gel. The developed in situ forming hydrogel could be a suitable delivery carrier of stem cells for soft tissue regeneration.
Cite this Research Publication : S. Deepthi and Dr. Jayakumar Rangasamy, “Alginate Nanobeads Interspersed Fibrin Network as in Situ Forming Hydrogel for Soft Tissue Engineering”, Bioactive Materials, vol. 3, pp. 194 - 200, 2018.