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Alginate Nanobeads Interspersed Fibrin Network as in Situ Forming Hydrogel for Soft Tissue Engineering

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Bioactive Materials

Source : Bioactive Materials

Url :

Keywords : Alginate nanobeads, Fibrin hydrogel, Soft tissue engineering

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2018

Abstract : Hydrogels are a class of materials that has the property of injectability and in situ gel formation. This property of hydrogels is manipulated in this study to develop a biomimetic bioresorbable injectable system of alginate nanobeads interspersed in fibrin network. Alginate nanobeads developed by calcium cross-linking yielded a size of 200–500 nm. The alginate nanobeads fibrin hydrogel was formed using dual syringe apparatus. Characterization of the in situ injectable hydrogel was done by SEM, FTIR and Rheometer. The developed hydrogel showed mechanical strength of 19 kPa which provides the suitable compliance for soft tissue engineering. Cytocompatibility studies using human umbilical cord blood derived mesenchymal stem cells showed good attachment, proliferation and infiltration within the hydrogel similar to fibrin gel. The developed in situ forming hydrogel could be a suitable delivery carrier of stem cells for soft tissue regeneration.

Cite this Research Publication : S. Deepthi and Dr. Jayakumar Rangasamy, “Alginate Nanobeads Interspersed Fibrin Network as in Situ Forming Hydrogel for Soft Tissue Engineering”, Bioactive Materials, vol. 3, pp. 194 - 200, 2018.

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