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An update on recent developments in the prevention and treatment of Staphylococcus aureus biofilms

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Medical Microbiology

Source : International Journal of Medical Microbiology, Elsevier GmbH, Volume 309, Number 1, p.1-12 (2019)

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Keywords : amylase, antibiofilm activity, antibiotic agent, antiinfective agent, biofilm, chelating agent, copper, deoxyribonuclease, dithiothreitol, ellagic acid, gold nanoparticle, hyaluronidase, iron, Lysostaphin, mercaptoethanol, nonhuman, Photodynamic therapy, phytochemistry, polypeptide antibiotic agent, Prevention and control, proteinase, review, selenium, shock wave, silver nanoparticle, Staphylococcus aureus, Staphylococcus infection, Staphylococcus phage, surface property, tannin, therapy effect, treatment planning, xanthohumol

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2018, 2019

Abstract : Staphylococcus aureus (S. aureus) readily forms biofilms on prosthetic devices such as the pacemakers, heart valves, orthopaedic implants, and indwelling catheters. Its biofilms are recalcitrant to antibiotic therapy and pose a serious burden in the healthcare setting as they drastically increase the treatment cost and morbidity of the patient. Prevention and treatment of staphylococcal biofilms has therefore been an area of active research for the past two decades. While catheters coated with different antiseptics and antibiotics capable of preventing S. aureus biofilm formation have been developed, an effective therapy for the dispersal and treatment of established staphylococcal biofilms is not yet available. Hence, many studies have focused on developing novel therapeutic strategies that can tackle established S. aureus biofilm associated infections. This has led to the identification of different phytochemicals (e.g., tannic acid, ellagic acid, xanthohumol etc), enzymes (e.g., Dnases, lysostaphin, α-amylase, hyaluronidase and proteases etc.), sulfahydrl compounds (e.g., dithiothreitol, 2-mercaptoethanol), nanoparticles (e.g., gold, silver, iron, copper and selenium), phage cocktails, antibodies and metal chelators. Apart from the conventional techniques, the therapeutic effects of ultra sound, shock waves and photodynamic therapy for treating S. aureus biofilms are also being investigated. Clinical validation of these studies will equip the medical field with alternate preventive and treatment methods against staphylococcal biofilm infections. This review provides recent updates on the preventive and therapeutic strategies explored to eradicate staphylococcal biofilm formation and related infections. © 2018 Elsevier GmbH

Cite this Research Publication : M. K. Suresh, Dr. Raja Biswas, and Lalitha Biswas, “An Update on Recent Developments in the Prevention and Treatment of Staphylococcus Aureus Biofilms”, International Journal of Medical Microbiology, vol. 309, pp. 1-12, 2019.

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