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An updated review of cyclodextrins -an enabling technology for challenging pharmaceutical formulations

Publisher : International Journal of Pharmacy and Pharmaceutical Sciences

Campus : Kochi

School : School of Pharmacy

Department : Pharmaceutics

Year : 2013

Abstract : Cyclodextrins (CDS) due to their complexation ability and other versatile characteristics, widely used in the field of pharmaceutical industry and in different areas of drug delivery system. Cyclodextrin molecules are relatively large molecules with number of hydrogen donors and acceptors, thus in general they do not permeate lipophilic membrane. CDS widely used to enhance the solubility, bioavailability, stability and safety of drug molecules. A number of cyclodextrin based product are now available in market, due to their ability to camouflage undesirable physiochemical properties of drugs. The aim of this review is to discuss about types of cyclodextrins, their use in delivery system, complexation techniques, also focus its use in novel drug delivery system and expected to solve many problems associated with the delivery of different novel drugs through different delivery routes. Studies in both human and animals have shown that cyclodextrins can be used to improve drug delivery from almost any type of drug formulations. However addition of cyclodextrin to any existing formulations without further optimisation will seldom result in acceptable outcome. The objective of this review article is to explain the use of natural and derivatized cyclodextrins in the different routes of administration.

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