Publication

Abstract : The most common cause of demen/a, Alzheimer's disease (AD), is an age-­‐ influenced chronic neurodegenera/ve progression affec/ng communica/on across mul/ple scales. Subcellular nano-­‐molecular changes within neurons along with extracellular neurofibrillary plaques or tangles combine to disrupt inter-­‐neural signaling and induce gradual loss of brain cogni/ve func/on. The subcellular ini/a/ng causes and factors influencing progression of AD would benefit by mathema/cal modeling of events to assist in understanding events in chemical signaling dysregula/on that underlies changes to both intra-­‐ and inter-­‐neural connec/vity. The dysregula/on of intracellular Ca 2+ is known to play a role in AD early pathology along with amyloid-­‐β (Aβ)