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Assessment of oxidative status in chronic pancreatitis and its relation with zinc status

Publication Type : Journal Article

Publisher : Indian Journal of Gastroenterology

Source : Indian Journal of Gastroenterology, Volume 30, Number 2, p.84-88 (2011)

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Keywords : adult, Alcoholic, alcoholic pancreatitis, antioxidant, Antioxidants, article, ascorbic acid, atomic absorption spectrometry, Chronic, chronic pancreatitis, clinical feature, controlled study, diabetic patient, enzyme activity, erythrocyte, female, glutathione, glutathione peroxidase, human, Humans, image analysis, lipid, lipid peroxidation, major clinical study, male, middle aged, oxidative stress, pancreatitis, Prospective Studies, prospective study, spectrophotometry, superoxide dismutase, thiobarbituric acid reactive substance, Thiobarbituric Acid Reactive Substances, tropical pancreatitis, vitamin blood level, Young Adult, zinc, zinc deficiency

Campus : Kochi

School : School of Medicine

Department : Physiology

Year : 2011

Abstract : Background: Oxidative stress-induced free radicals have been implicated in the pathology of chronic pancreatitis (CP). Aim: We aimed to estimate oxidative stress and antioxidant status in tropical chronic pancreatitis (TCP) and alcoholic chronic pancreatitis (ACP) and correlate with zinc status. Methods: One hundred and seventy-five CP patients (91 TCP, 84 ACP) and 113 healthy subjects were prospectively studied. Disease characteristics and imaging features were recorded. Erythrocyte reduced glutathione, glutathione peroxidase (GPx), superoxide dismutase (SOD), plasma vitamin C, and erythrocyte thiobarbituric acid reactive substance (TBARS) were estimated by spectrophotometry. Erythrocyte zinc was estimated by flame atomic absorption spectrophotometry. Results: Enhanced lipid peroxidation with concomitant decrease in antioxidant status was observed in both TCP and ACP patients (p 0.05). The findings were comparable in both diabetic and non-diabetic CP patients. Significantly, lower plasma vitamin C and elevated levels of erythrocyte TBARS was noted in TCP as compared to ACP patients. The erythrocyte zinc significantly correlated with SOD activity (r = 0.450, p 0.001). Conclusions: Our study corroborates the role of oxidative stress in CP and suggests some differences in oxidative status in TCP and ACP patients. Zinc deficiency appears to affect oxidative status in CP patients. © 2011 Indian Society of Gastroenterology.

Cite this Research Publication : B. Na Girish, Rajesh, Gb, Vaidyanathan, Kc, and Balakrishnan, Vb, “Assessment of oxidative status in chronic pancreatitis and its relation with zinc status”, Indian Journal of Gastroenterology, vol. 30, pp. 84-88, 2011.

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