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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Nano Letters
Source : Nano Letters, Volume 13, Number 9, p.4410-4415 (2013)
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Verified : Yes
Year : 2013
Abstract : The extracellular matrix (ECM) has a quasi-ordered reticular mesostructure with feature sizes on the order of tenths of to a few hundred nanometers. Approaches to preparing biodegradable synthetic scaffolds for engineered tissues that have the critical mesostructure to mimic ECM are few. Here we present a simple and general solvent evaporation-induced self-assembly (EISA) approach to preparing concentrically reticular mesostructured polyol–polyester membranes. The mesostructures were formed by a novel self-assembly process without covalent or electrostatic interactions, which yielded feature sizes matching those of ECM. The mesostructured materials were nonionic, hydrophilic, and water-permeable and could be shaped into arbitrary geometries such as conformally molded tubular sacs and micropatterned meshes. Importantly, the mesostructured polymers were biodegradable and were used as ultrathin temporary substrates for engineering vascular tissue constructs.
Cite this Research Publication : B. Tian, Dr. Sahadev Shankarappa, Chang, H. H., Tong, R., and Kohane, D. S., “Biodegradable Mesostructured Polymer Membranes”, Nano Letters, vol. 13, pp. 4410-4415, 2013.