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Bioglass-Incorporated Methacrylated Gelatin Cryogel for Regeneration of Bone Defects

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Polymers

Source : Polymers, Volume 10, Number 8 (2018)

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Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2018

Abstract : Cryogels have recently gained interest in the field of tissue engineering as they inherently possess an interconnected macroporous structure. Considered to be suitable for scaffold cryogel fabrication, methacrylated gelatin (GelMA) is a modified form of gelatin valued for its ability to retain cell adhesion site. Bioglass nanoparticles have also attracted attention in the field due to their osteoinductive and osteoconductive behavior. Here, we prepare methacrylated gelatin cryogel with varying concentration of bioglass nanoparticles to study its potential for bone regeneration. We demonstrate that an increase in bioglass concentration in cryogel leads to improved mechanical property and augmented osteogenic differentiation of mesenchymal cells during in vitro testing. Furthermore, in vivo testing in mice cranial defect model shows that highest concentration of bioglass nanoparticles (2.5 w/w %) incorporated in GelMA cryogel induces the most bone formation compared to the other tested groups, as studied by micro-CT and histology. The in vitro and in vivo results highlight the potential of bioglass nanoparticles incorporated in GelMA cryogel for bone regeneration.

Cite this Research Publication : S. Kwon, Lee, S. S., Sivashanmugam, A., Kwon, J., Kim, S. Hyun L., Noh, M. Yeon, Kwon, S. Keun, Dr. Jayakumar Rangasamy, and Hwang, N. S., “Bioglass-Incorporated Methacrylated Gelatin Cryogel for Regeneration of Bone Defects”, Polymers, vol. 10, 2018.

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