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Biosynthesis of furanochromones inPimpinella monoica

Publication Type : Conference Proceedings

Thematic Areas : Biotech

Publisher : Springer

Source : Proceedings of the Indian Academy of Sciences-Chemical Sciences, Springer, Volume 106, p.1149-1156 (1994)

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Campus : Amritapuri

School : School of Biotechnology

Center : Biotechnology, Phytochemistry Labs

Department : biotechnology, Chemistry

Year : 1994

Abstract : During a search for bioactive compounds from indigenous plants,Pimpinella monoica (Umbelliferae) was found to contain furocoumarin, isopimpenellin (3) and five biogenetically related furocoumarins viz khellin (1), visnagin (2), visamminol (4), ammiol (5) and khellol (6). Labelled (i) and (2) were isolated from [1−14C]- and [2−14C]-acetates. Labelling pattern, determined by degradation of biosynthesised compounds, establishes the polyketide origin of their aromatic and pyrone rings while the furan ring originates via an acetate-mevalonate pathway. The plant also utilises glycine and leucine as substratevia acetate. Biotransformation of [3−3H]-visnagin to (6) but not to (2) was also observed.

Cite this Research Publication : D. L. Luthria and Banerji, A., “Biosynthesis of furanochromones inPimpinella monoica”, Proceedings of the Indian Academy of Sciences-Chemical Sciences, vol. 106. Springer, pp. 1149-1156 , 1994.

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