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Comparison of quality of life in advanced laryngeal cancer patients after concurrent chemoradiotherapy vs total laryngectomy

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Otolaryngology - Head and Neck Surgery

Source : Otolaryngology - Head and Neck Surgery, Volume 139, Number 5, p.702-707 (2008)

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Keywords : Adjuvant, adult, advanced cancer, aged, Antineoplastic Agents, article, cancer chemotherapy, cancer radiotherapy, Carcinoma, Chemotherapy, clinical article, controlled study, Cross-Sectional Studies, disease free interval, female, Follow-Up Studies, functional assessment, human, Humans, Karnofsky Performance Status, Laryngeal Neoplasms, laryngectomy, larynx cancer, male, middle aged, Neoplasm Staging, outcome assessment, quality of life, questionnaire, Radiotherapy, treatment outcome, xerostomia

Campus : Kochi

School : School of Medicine

Department : Head & Neck Surgery

Year : 2008

Abstract : Objective: To compare quality of life (QOL) of patients with advanced laryngeal cancers treated by total laryngectomy with those who received concurrent chemoradiotherapy. Study Design: This is a cross-sectional study of the patients treated in our institution who have completed one year of follow-up and were disease-free at the time of evaluation. Subjects and Method: Forty patients treated for advanced cancer of the larynx (stage III/IV), either by concurrent chemoradiation (11) or total laryngectomy and postoperative radiation (29), have been included in this study. The Functional Assessment of Cancer Therapy-Head and Neck (FACT-HN) version 4 questionnaire was used. Results: Total scores for overall QOL are equal in both treatment groups (P = 0.69). Scores for individual components are similar in both treatment groups. However, dryness of mouth is significantly worse in the chemoradiotherapy group (P = 0.01) and ability to communicate with others is poorer in the laryngectomy group (P = 0.03). Conclusion: Long-term overall QOL remains similar in all the patients treated for advanced carcinoma of the larynx irrespective of treatment modality. © 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation.

Cite this Research Publication : N. P. Trivedi, Swaminathan, D. K., Thankappan, K., Chatni, S., Kuriakose, M. A., and Dr. Subramania Iyer K., “Comparison of quality of life in advanced laryngeal cancer patients after concurrent chemoradiotherapy vs total laryngectomy”, Otolaryngology - Head and Neck Surgery, vol. 139, pp. 702-707, 2008.

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