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Publication Type : Conference Proceedings
Publisher : 26th Annual Symposium of Indian Society for Atherosclerosis.
Source : Abstract pg 82. 26th Annual Symposium of Indian Society for Atherosclerosis. November 22-23, 2013. Amala Cancer Research Centre, Thrissur, Kerala.
Campus : Amritapuri
School : School of Biotechnology
Department : biotechnology
Year : 2013
Abstract : Cardiac hypertrophy occurs in response to increased workload, such as hypertension or valvular heart disease. Oxidative stress has been implicated in cardiac hypertrophy and in its transition to heart failure. This study was taken up with the objective to evaluate the role of oxidative stress in cardiomyoblast hypertrophy and its modulation by Desmodium gangeticum (DG) that has been traditionally used in Ayurveda, an Indian system of medicine. The methanolic root extract was analyzed for total phenolic content and tested for antioxidant potential. Hypertrophy was induced by exposing H9c2 cell line to β-adrenergic receptor agonist, isoproterenol (ISO), for 96 hours. Analyses of reactive oxygen species (ROS) generation, mitochondrial transmembrane potential ([INCREMENT]Ψm), and integrity of permeability transition were performed in ISO as well as Desmodium and ISO-cotreated cells. The results demonstrated potent free radical scavenging activity of DG. Cell line studies showed significant increase in ROS generation, dissipation of [INCREMENT]Ψm, and permeability transition pore opening in ISO-treated cells. Desmodium was found to attenuate ISO-induced hypertrophy by reduction of ROS generation, restoration of [INCREMENT]Ψm, and prevention of permeability transition pore opening. This study is the first documentation of the modulatory effect of DG on cardiac hypertrophy.
Cite this Research Publication : Desmodium gangeticum (Linn.) DC. exhibits antihypertrophic effect in isoproterenol- stimulated cardiomyoblasts via amelioration of oxidative stress and mitochondrial alterations. Vandana Sankar, Raghu KG. Abstract pg 82. 26th Annual Symposium of Indian Society for Atherosclerosis. November 22-23, 2013. Amala Cancer Research Centre, Thrissur, Kerala.