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Development of a phytochemical scaffold for bone tissue engineering using Cissus quadrangularis extract

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 87, Number 2, p.1787-1795 (2012)

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Keywords : Alginate, Biological properties, Biopolymers, Bone, Bone tissue engineering, Cell attachments, Cell culture, chitosan, Cissus quadrangularis, Composite scaffolds, Cytocompatibility, Fourier transform infrared spectroscopy, FTIR, hMSCs, Human mesenchymal stem cells (hMSCs), Hybrid scaffolds, Medicinal plants, Mineral depositions, Natural biopolymers, O-Carboxymethyl chitosan, O-carboxymethyl chitosans, Osteogenic media, Physico-chemicals, Plant Extracts, Scaffolds (biology), scanning electron microscopy, Stem cells, Tissue, X ray diffraction analysis, XRD

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2012

Abstract : A novel herbal scaffold (Alg/O-CMC/CQ-E scaffold) was fabricated by incorporating medicinal plant Cissus quadrangularis (CQ) extract with natural biopolymers alginate (Alg) and O-carboxymethyl chitosan (O-CMC) by lyophilization technique The prepared composite scaffolds were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction analysis (XRD). Preliminary cytocompatibility studies with human mesenchymal stem cells (hMSCs) supports the biocompatible nature of the composite scaffolds. There was a significant difference in initial cell attachment and proliferation on the herbal scaffolds compared to scaffolds fabricated without extract. Moreover, the hybrid scaffold favoured a substantially enhanced differentiation of hMSCs to osteoblasts, even without osteogenic media supplements, followed by increased calcified mineral deposition within two weeks of incubation. Hence, our primary investigation of physico-chemical and biological properties of the herbal scaffolds suggests that this osteoinductive scaffold could serve as a potential candidate for bone tissue engineering therapeutics. © 2011 Elsevier Ltd. All rights reserved.

Cite this Research Publication : S. Soumya, Sajesh, K. M., Dr. Jayakumar Rangasamy, Shantikumar V. Nair, and Chennazhi, K. P., “Development of a phytochemical scaffold for bone tissue engineering using Cissus quadrangularis extract”, Carbohydrate Polymers, vol. 87, pp. 1787-1795, 2012.

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