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Development of Novel α-chitin/nanobioactive Glass Ceramic Composite Scaffolds for Tissue Engineering Applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 78, Number 4, p.926 - 931 (2009)

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Keywords : Bioactive glass ceramic nanoparticles, Biomaterials, chitin, Composite scaffolds, tissue engineering

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2009

Abstract : Bioactive glass ceramic nanoparticles (nBGC) were prepared by sol–gel technique. The novel chitin/nBGC composite scaffolds were prepared using chitin gel with nBGC by lyophilization technique. The prepared nBGC and composite scaffolds were characterized using Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Fourier Transformed Infrared Spectroscopy (FT-IR) and X-ray diffraction (XRD). The composite scaffolds showed adequate porosity where the nBGC nanoparticles were homogenously distributed on the pore walls. The swelling, density, degradation and in vitro biomineralization capability of the composite scaffolds were also evaluated. The developed composite scaffolds showed adequate swelling and degradation properties along with its ability to become bioactive. Cytocompatability of the scaffolds was assessed using MTT assay, direct contact test and cell attachment studies. Results indicated no sign of toxicity and cells found to be attached to the pore walls offered by the scaffolds. These results suggested that the developed composite scaffold possess the prerequisites for tissue engineering scaffolds and it can be used for tissue engineering applications.

Cite this Research Publication : M. Peter, Kumar, P. Thodi Sudh, Binulal, N. Sathy, Nair, S. V., Tamura, H., and Dr. Jayakumar Rangasamy, “Development of Novel α-chitin/nanobioactive Glass Ceramic Composite Scaffolds for Tissue Engineering Applications”, Carbohydrate Polymers, vol. 78, pp. 926 - 931, 2009.

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