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Differing Aetiology of Acute Liver Failure in India, Compared to Other Countries

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Liver transplantation

Source : Liver transplantation , Volume 19, p.S123-S123 (2013)

Campus : Kochi

School : School of Medicine

Department : Gastrointestinal Surgery

Year : 2013

Abstract : Background Acute liver failure (ALF) is a critical illness with a large number of viral and nonviral causes. Clinical course and etiologies in the Asian countries are different from those reported from the Western world and mortality is high. There may even be intracountry variations in large countries like India, which have differing culture, ethnicity, and environment. Data from North-east part of India is lacking. Materials and methods Acute liver failure cases (>14 years of age) seen over a period of 8 years (n = 255) were studied at a Government Medical College in Assam for their etiological and other demographic profile. Viral serology was carried out and revalidated at a laboratory in New Delhi. Results Majority of cases were <30 years of age. Commonest etiology was nonviral (non-ABCE). Amongst viral causes, hepatitis A and E were common, while hepatitis B virus (HBV) was rare. Unknown herbal medication use was very frequent in our cases with a significantly higher mortality. Mortality was highest in cases in 3rd decade of life. Statistically, international normalized ratio (INR) was the strongest predictor of death.

Cite this Research Publication : Z. Shemin, Eapen, M., Jojo, A., and Dr. Sudhindran S., “Differing Aetiology of Acute Liver Failure in India, Compared to Other Countries.”, Liver transplantation , vol. 19, pp. S123-S123, 2013.

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