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Drug delivery and tissue engineering applications of biocompatible pectin-chitin/nano CaCO3 composite scaffolds

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Colloids and Surfaces B: Biointerfaces

Source : Colloids and Surfaces B: Biointerfaces, Volume 106, p.109-116 (2013)

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Keywords : alendronic acid, Animals, article, biocompatibility, Biocompatible Materials, Biomedical applications, biomineralization, Bisphosphonates, calcium carbonate, cell adhesion, Cell attachments, Cell Line, cell proliferation, cell strain 3T3, cell viability, Cells, chitin, Composite scaffolds, controlled study, Cytocompatibility, Cytology, degradation kinetics, Drug delivery, drug delivery system, Drug Delivery Systems, drug formulation, Electron, Fourier Transform Infrared, Fourier transform infrared spectroscopy, human, human cell, Human dermal fibroblasts, Humans, in vitro study, infrared spectroscopy, Medical applications, Mice, microscopy, molecular scaffold, Nano-CaCO, nanocomposite, Nanocomposite scaffolds, Nanocomposites, Pectin, Pectins, porosity, priority journal, Scaffolds (biology), Scanning, scanning electron microscopy, Spectroscopy, tissue engineering, Tissue engineering applications, Tissue Scaffolds, water absorption, X ray diffraction, X-Ray Diffraction

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2013

Abstract : In this work, we have developed a nanocomposite scaffold using a mixture of pectin, chitin and nano CaCO3 using the technique of lyophilization, with an intended use towards biomedical applications such as tissue engineering and drug delivery. The prepared composite scaffold was characterized using scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). In addition, swelling, degradation and biomineralization capability of the composite scaffold was evaluated. The developed composite scaffold showed controlled swelling and degradation in comparison with the control scaffold. Cytocompatibility evaluation of the scaffold was tested on NIH3T3, L929 and human dermal fibroblast (HDF) cells, showed negligible toxicity towards cells. Cell attachment and proliferation studies were also conducted using these cells, which showed that cells attached onto the scaffolds and started to proliferate after 48h of incubation. Further, drug delivery through the scaffold was examined using a bisphosphonate called Fosamax. These results suggest that the developed composite scaffold possess the essential requisites for their application in the fields of tissue engineering and drug delivery. © 2013 Elsevier B.V.

Cite this Research Publication : P. T. S. Kumar, Ramya, C., Dr. Jayakumar Rangasamy, Nair, S. K. V., and Lakshmanan, V. - K., “Drug delivery and tissue engineering applications of biocompatible pectin-chitin/nano CaCO3 composite scaffolds”, Colloids and Surfaces B: Biointerfaces, vol. 106, pp. 109-116, 2013.

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