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Effect of ethanol on liver antioxidant defense systems: A dose dependent study

Publication Type : Journal Article

Publisher : Indian Journal of Clinical Biochemistry

Source : Indian Journal of Clinical Biochemistry, Volume 20, Number 1, p.80-84 (2005)

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Keywords : adipose tissue, alcohol, alcohol consumption, alcohol metabolism, animal experiment, animal model, animal tissue, Animalia, antioxidant activity, article, ascorbic acid, body weight, catalase, controlled study, dose response, enzyme activity, glucose 6 phosphate dehydrogenase, glutathione, glutathione peroxidase, glutathione reductase, glutathione transferase, lipid peroxidation, liver metabolism, liver weight, male, nonhuman, oxidative stress, rat, reduced nicotinamide adenine dinucleotide phosphate, superoxide, superoxide dismutase, thiobarbituric acid reactive substance, weight gain

Campus : Kochi

School : School of Medicine

Year : 2005

Abstract : Alcohol induced oxidative stress is linked to the metabolism of ethanol. In this study it has been observed that administration of ethanol in lower concentration caused gain in body and liver weight, while higher concentration of ethanol caused lesser gain in body and liver weight. Ethanol treatment enhanced lipid peroxidation significantly, depletion in levels of hepatic glutathione and ascorbate, accompanied by a decline in the activities of glutathione peroxidase and glutathione reductase, and increased in hepatic glutathione s-transferase activity. Interestingly catalase activity increased in lower concentration of ethanol exposure, and decreased in higher concentration. Superoxide dismutase activity was also increased on ethanol exposure. But, ethanol feeding did not show any effect on glucose-6- phosphate dehydrogenase activity. Ethanol ingestion perturbs the antioxidant system in a dose and time dependent manner.

Cite this Research Publication : S. K. Das and Dr. Damodaran Vasudevan, “Effect of ethanol on liver antioxidant defense systems: A dose dependent study”, Indian Journal of Clinical Biochemistry, vol. 20, pp. 80-84, 2005.

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