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Effects of chronic ethanol consumption in blood: a time dependent study on rat

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Springer

Source : Indian Journal of Clinical Biochemistry, Springer, Volume 24, Issue 3, Number 3, p.301–306 (2009)

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Keywords : Ethanol Glutathione Liver function Nitric oxide Oxidative stress Transforming growth factor Vascular endothelial growth factor

Campus : Kochi

School : School of Medicine

Department : Biochemistry

Year : 2009

Abstract : Alcohol consumption and health outcomes are complex and multidimensional. Ethanol (1.6g / kg body weight/ day) exposure initially affects liver function followed by renal function of 16–18 week-old male albino rats of Wistar strain weighing 200–220 g. Chronic ethanol ingestion increased in thiobarbituric acid reactive substances level and glutathione s-transferase activity; while decreased reduced gluatathione content and activities of catalase, glutathione peroxidase and glutathione reductase in a time dependent manner in the hemolysate. Though superoxide dismutase activity increased initially might be due to adaptive response, but decreased later. Elevation of serum nitrite level and transforming growth factor-b1 activity indicated that long-term ethanol consumption may cause hepatic fibrosis and can elicit pro-angiogenic factors. However, no alteration in vascular endothelial growth factor-C activity indicated that ethanol consumption is not associated with lymphangiogenesis. Therefore, we conclude that long-term ethanol-induced toxicity is linked to an oxidative stress, which may aggravate to fibrosis and elevate pro-angiogenic factors, but not associated with lymphangiogenesis.

Cite this Research Publication : S. Kumar Das, Dhanya, L., Varadhan, S., Mukherjee, S., and Vasudevan, D. M., “Effects of chronic ethanol consumption in blood: a time dependent study on rat”, Indian Journal of Clinical Biochemistry, vol. 24, no. 3, pp. 301–306, 2009.

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