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Fabrication of chitin-chitosan/nano ZrO2 composite scaffolds for tissue engineering applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Biological Macromolecules

Source : International Journal of Biological Macromolecules, Volume 49, Number 3, p.274-280 (2011)

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Keywords : article, biocompatibility, Biocompatible Materials, biodegradation, biomineralization, cell adhesion, Cell Line, Cell Survival, cell viability, chitin, chitosan, controlled study, cytotoxicity, freeze drying, human, human cell, Humans, Minerals, molecular scaffold, nanocomposite, Nanocomposites, nanofabrication, porosity, tissue engineering, Tissue Scaffolds, Tumor, Zirconium, zirconium oxide

Campus : Kochi

School : Center for Nanosciences, School of Dentistry

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Periodontics, Nanosciences and Molecular Medicine

Year : 2011

Abstract : The urge to repair and regenerate natural tissues can now be satisfactorily fulfilled by various tissue engineering approaches. Chitin and chitosan are the most widely accepted biodegradable and biocompatible materials subsequent to cellulose. The incorporation of nano ZrO2 onto the chitin-chitosan scaffold is thought to enhance osteogenesis. Hence a nanocomposite scaffold was fabricated by lyophilization technique using chitin-chitosan with nano ZrO2. The prepared nanocomposite scaffolds were characterized using SEM, FTIR, XRD and TGA. In addition, the swelling, degradation, biomineralization, cell viability and cell attachment of the composite scaffolds were also evaluated. The results demonstrated better swelling and controlled degradation in comparison to the control scaffold. Cell viability studies proved the non toxic nature of the nanocomposite scaffolds. Cells were found to be attached to the pore walls and spread uniformly throughout the scaffolds. All these results suggested that the developed nanocomposite scaffolds possess the prerequisites for tissue engineering scaffolds and could be used for various tissue engineering applications. © 2011 Elsevier B.V.

Cite this Research Publication : Dr. Jayakumar Rangasamy, Ramachandran, R., Kumar, P. T. Sudheesh, Divyarani, V. V., Sowmya Srinivasan, Chennazhi, K. P., Tamura, H., and Nair, S. V., “Fabrication of chitin-chitosan/nano ZrO2 composite scaffolds for tissue engineering applications”, International Journal of Biological Macromolecules, vol. 49, pp. 274-280, 2011.

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