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Galactose decorated PLGA nanoparticles for hepatic delivery of acyclovir

Publication Type : Journal Article

Publisher : Drug Development and Industrial Pharmacy

Source : Drug Development and Industrial Pharmacy, vol. 39, pp. 1866-1873, 2013.

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Keywords : aciclovir, area under the curve, article, controlled study, drug bioavailability, drug delivery system, drug distribution, drug elimination, drug half life, drug targeting, fluorescence microscopy, galactose, Hemolysis, in vitro study, in vivo study, infrared spectroscopy, liver, maximum plasma concentration, mean residence time, mouse, nanoencapsulation, nanoparticle, nonhuman, particle size, polyglactin, scanning electron microscopy, sustained drug release, zeta potential

Campus : Kochi

School : School of Pharmacy

Department : Pharmaceutics

Year : 2013

Abstract : The present study explores prospective of surface tailored nanoparticles for targeted delivery of acyclovir along with the interception of minimal side effects. Acyclovir loaded plain and galactosylated poly lectic co glycolic acid (PLGA) nanoparticles were efficiently prepared and characterized by Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), size, polydispersity index, zeta potential, and entrapment efficiency. The formulations were evaluated for in vitro drug release and hemolysis. Further, biodistribution study and fluorescent microscopic studies were carried out to determine the targeting potential of formulations. SEM revealed smooth morphology and spherical shape of the nanoparticles. In vitro, the galactosylated nanoparticles were found to be least hemolytic and exhibited a sustained release pattern. In vivo studies exhibited an augmented bioavailability, increased residence time and enhanced delivery of acyclovir to the liver upon galactosylation. It may therefore be concluded that galactose conjugated PLGA nanoparticles can be used suitably as vehicles for delivery of bioactives specifically to the hepatic tissues and may be thus exploited in the effective management of various liver disorders. © 2013 Informa Healthcare USA, Inc.

Cite this Research Publication : Swati P. Gupta, Agarwal, Aa, Gupta, N. Kac, Saraogi, Ga, Agrawal, Hd, and Agrawal, G. Pa, “Galactose decorated PLGA nanoparticles for hepatic delivery of acyclovir”, Drug Development and Industrial Pharmacy, vol. 39, pp. 1866-1873, 2013.

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