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Publication Type : Journal Article
Publisher : Food and Chemical Toxicology
Source : Food and Chemical Toxicology, Volume 49, Number 12, p.3367-3373 (2011)
Keywords : Acanthaceae, Acetaminophen, Administration, alanine aminotransferase, alanine aminotransferase blood level, Alanine Transaminase, alkaline phosphatase, alkaline phosphatase blood level, Andrographis, Andrographis paniculata, Andrographis paniculata extract, animal experiment, animal model, animal tissue, Animals, article, aspartate aminotransferase, aspartate aminotransferase blood level, Aspartate Aminotransferases, bilirubin, bilirubin blood level, Biological Markers, catalase, controlled study, dose response, drug effect, drug efficacy, Drug-Induced Liver Injury, female, Gentianaceae, glutathione, glutathione peroxidase, India, lipid blood level, lipid peroxidation, lipid peroxide, Lipid Peroxides, liver, liver enzyme, liver parenchyma, liver protection, liver protective agent, liver toxicity, Medicinal, Mice, mouse, Mus, nonhuman, Oral, phytochemistry, plant extract, Plant Extracts, Plants, Silymarin, superoxide dismutase, Swertia, Swertia chirayita, Swertia chirayita extract, treatment duration, unclassified drug
Campus : Kochi
School : School of Pharmacy
Year : 2011
Abstract : Andrographis paniculata (Family: Acanthaceae) and Swertia chirayita (Family: Gentianaceae) are two controversial medicinal plants used as Kiriyattu, having similar therapeutic action and are used as a hepatoprotective and hepatostimulative agent. A. paniculata grows in southern parts of India and S. chirayita in the Himalayan region. The present work concerns on the ability of the extracts of these plants to offer protection against acute hepatotoxicity induced by paracetamol (150. mg/kg) in Swiss albino mice. Oral administration of A. paniculata or S. chirayita extract (100-200. mg/kg) offered a significant dose dependent protection against paracetamol induced hepatotoxicity as assessed in terms of biochemical and histopathological parameters. The paracetamol induced elevated levels of serum marker enzymes such as serum glutamate pyruvate transaminase (GPT), serum glutamate oxaloacetate transaminase (GOT), alkaline phosphatase (ALP), and bilirubin in peripheral blood serum and distorted hepatic tissue architecture along with increased levels of lipid peroxides (LPO) and reduction of superoxide dismutase (SOD), catalase, reduced glutathione (GSH) and glutathione peroxidase (GPx) in liver tissue. Administration of the plant extracts after paracetamol insult restored the levels of these parameters to control (untreated) levels. Thus the present study revealed that the extracts of A. paniculata or S. chirayita offered protection against hepatotoxicity induced by paracetamol. © 2011 Elsevier Ltd.
Cite this Research Publication : Ra Nagalekshmi, Menon, Ab, Chandrasekharan, D. Kb, and Nair, C. K. Kc, “Hepatoprotective activity of Andrographis Paniculata and Swertia Chirayita”, Food and Chemical Toxicology, vol. 49, pp. 3367-3373, 2011.