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Hyaluronic Acid-based Conjugates for Tumor-targeted Drug Delivery and Imaging

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Journal of Biomedical Nanotechnology

Source : Journal of Biomedical Nanotechnology, Volume 10, Number 1, p.17-31 (2014)

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Keywords : Activated macrophages, Biological properties, Conjugate, drug delivery system, Imaging agent, Receptor-mediated endocytosis, Tumor-targeted drug deliveries

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2014

Abstract : In recent years, hyaluronic acid (HA) has attracted significant interest in development of drug delivery systems because of its intrinsic physicochemical and biological properties, including water solubility, viscoeleasticity, non-immunogenicity, biocompatibility, and biodegradability. In addition, HA has the ability to selectively bind specific receptors on the disease-related cells such as cancer cells and activated macrophages, followed by receptor-mediated endocytosis. Owing to these unique features, HA has been extensively used for development of the targetable carriers to deliver the therapeutic and imaging agents. In this review, we discuss the recent progress in various HA-based conjugates for cancer therapy and imaging, in which the active agents are covalently conjugated or physically encapsulated. Copyright

Cite this Research Publication : G. Saravanakumar, Deepagan, V. G., Dr. Jayakumar Rangasamy, and Park, J. H., “Hyaluronic Acid-based Conjugates for Tumor-targeted Drug Delivery and Imaging”, Journal of Biomedical Nanotechnology, vol. 10, pp. 17-31, 2014.

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