Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Colloids and Surfaces B: Biointerfaces
Source : Colloids and Surfaces B: Biointerfaces, Volume 104, p.245-253 (2013)
Url : http://www.scopus.com/inward/record.url?eid=2-s2.0-84872666017&partnerID=40&md5=9fd23320276e7f6ed20120b820d838fa
Keywords : Anticancer activities, antineoplastic activity, Antineoplastic Agents, Antitumor, apoptosis, article, Average diameter
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences
Verified : Yes
Year : 2013
Abstract : Chitin and its derivatives have been widely used in drug delivery applications due to its biocompatible, biodegradable and non-toxic nature. In this study, we have developed amorphous chitin nanoparticles (150 ± 50. nm) and evaluated its potential as a drug delivery system. Paclitaxel (PTX), a major chemotherapeutic agent was loaded into amorphous chitin nanoparticles (AC NPs) through ionic cross-linking reaction using TPP. The prepared PTX loaded AC NPs had an average diameter of 200 ± 50. nm. Physico-chemical characterization of the prepared nanoparticles was carried out. These nanoparticles were proven to be hemocompatible and in vitro drug release studies showed a sustained release of PTX. Cellular internalization of the NPs was confirmed by fluorescent microscopy as well as by flow cytometry. Anticancer activity studies proved the toxicity of PTX-AC NPs toward colon cancer cells. These preliminary results indicate the potential of PTX-AC NPs in colon cancer drug delivery. © 2012 Elsevier B.V.
Cite this Research Publication : K. T. Smitha, Anitha, A., Furuike, T., Tamura, H., Nair, S. V., and Dr. Jayakumar Rangasamy, “In Vitro Evaluation of Paclitaxel Loaded Amorphous Chitin Nanoparticles for Colon Cancer Drug Delivery”, Colloids and Surfaces B: Biointerfaces, vol. 104, pp. 245-253, 2013.