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Incretin analogue, liraglutide a newer treatment approach for type-2 diabetes mellitus

Publisher : International Journal of Pharma and Bio Sciences

Campus : Kochi

School : School of Pharmacy

Department : Pharmacy Practice

Year : 2013

Abstract : Glucagon-like peptide 1 (GLP-1) receptor agonists, are one among the latest addition of medication included for the management of type 2 diabetes. Liraglutide, a novel long acting glucagon-like peptide analogue, is effective at improving indices of glycemic control. It has good tolerability and safety profile. It acts in a glucose-dependent manner. In controlled trials, it was observed that it produce short-term glucose lowering effects, with the reduction of HbA1C of up to 1.3 % which is comparable with oral agents. The beneficial effects observed for liraglutide was on reduction of weight (1-3.4 kg) and blood pressure (2.1-6.7mmHg). The formation of antibodies against Liraglutide was comparatively less than that of exenatide. The effects of liraglutide on beta-cell function, cardiovascular risk and disease progression are anticipated from long-term clinical trials results. There are on-going or in development trials exploring the effects of liraglutide in prediabetes, obesity and type 1 diabetes.

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