Publisher : Letters in Organic Chemistry
Campus : Coimbatore
School : School of Engineering
Department : Sciences
Year : 2018
Abstract : pThe Knoevenagel reaction is one of the most useful methods for the synthesis of α, β- unsaturated nitriles. We disclose an efficient protocol for the Knoevenagel reaction of aldehydes with malononitrile catalyzed by 1-alkyl-1, 2, 4-triazolium salts to afford the corresponding products in excellent yields. The important feature of this reaction is the catalyst; 1-alkyl-1, 2, 4-triazolium salts are recycled and reused. Furthermore, the reaction conditions are environment friendly and do not produce any hazardous waste. © 2018 Bentham Science Publishers./p