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Knoevenagel reaction catalyzed by a reusable Brønsted acid based on 1-alkyl-1, 2, 4-triazolium tetrafluoroborate

Publisher : Letters in Organic Chemistry

Campus : Coimbatore

School : School of Engineering

Department : Sciences

Year : 2018

Abstract : pThe Knoevenagel reaction is one of the most useful methods for the synthesis of α, β- unsaturated nitriles. We disclose an efficient protocol for the Knoevenagel reaction of aldehydes with malononitrile catalyzed by 1-alkyl-1, 2, 4-triazolium salts to afford the corresponding products in excellent yields. The important feature of this reaction is the catalyst; 1-alkyl-1, 2, 4-triazolium salts are recycled and reused. Furthermore, the reaction conditions are environment friendly and do not produce any hazardous waste. © 2018 Bentham Science Publishers./p

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