Back close

Molecular Docking, Synthesis and CNS Activity of Some Novel 1, 4-Benzodiazepine Derivatives

Publication Type : Journal Article

Source : (2017)

Url :

Keywords : 1, 4-benzodizepines, antianxiety, antiepileptic, diazepam., GABAA, molecular docking

Campus : Kochi

School : School of Pharmacy

Center : Amrita Institute of Medical Science

Department : Pharmaceutical Chemistry & Analysis

Year : 2017

Abstract : Background: A series of new class of twenty four 1, 4-benzodizepines were designed andby using molecular docking study with GABAA receptor, high scoring fourteen molecules weresynthesized from this library. Binding affinity of ligands towards GABAA was evaluated on the basis ofdock score and bonding interactions like hydrogen bonds, hydrophobic bonds and pi-stacking.Methods: All compounds were found to possess a good dock score, but varied in the formation ofbonding interactions. Methoxy group substituted ligands showed particularly very important role inthese interactions. All the synthesized molecules were characterized by IR, 1H-NMR and Massspectrometric data and investigated for their antianxiety and antiepileptic actions.Conclusion: Compound 3-(3-ethoxy-4-hydroxybenzylidene)-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one was found to possess very effective in both the activities. All results, docking as well aspharmacological evaluations were compared to diazepam.

Cite this Research Publication : S. S. Menghani*, Chikhale, R., Pant, A., Bijo Mathew, and Khedekar, P., “Molecular Docking, Synthesis and CNS Activity of Some Novel 1, 4-Benzodiazepine Derivatives”, 2017.

Admissions Apply Now