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Nocardia farcinica brain abscess: epidemiology, pathophysiology, and literature review

Publication Type : Journal Article

Publisher : Surgical infections

Source : Surg Infect, 2014

Url :

Campus : Kochi

School : School of Medicine

Department : Microbiology

Verified : Yes

Year : 2014

Abstract : Background: Infections caused by Nocardia farcinica are potentially lethal because of the organism's tendency to disseminate and resist antibiotics. Central nervous system involvement has been documented in 30% of infections caused N. farcinica.Methods: Case report and review of the literature.Results: A case of primary brain abscess caused by N. farcinica, identified by 16SrRNA sequencing, is presented, and 39 cases reported previously in the literature are reviewed. Our patient underwent a neuronavigation-guided right frontal craniotomy and was treated with trimethoprim/sulfamethoxazole and amoxicillin-clavulanic acid for 12 mo. He showed marginal improvement in his prior left hemiparesis at the last review 14 months later.Conclusion: Cases of N. farcinica infections are being reported increasingly because of recent changes in taxonomy and diagnostic methodology. This change in epidemiology has implications for therapy because of the organism's pathogenicity and natural resistance to multiple antimicrobial agents, including third-generation cephalosporins. Any delay in starting appropriate antibiotic therapy can have adverse consequences.

Cite this Research Publication : V. Anil Kumar, Deepthi Augustine, Dilip Panikar, Aswathy Nandakumar, Kavitha R. Dinesh, Shamsul Karim, and Rosamma Philip "Nocardia farcinica Brain Abscess: Epidemiology, Pathophysiology, and Literature Review", Surg Infect, 2014

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